Checkpoint Inhibitors Side Effects

Mp inflammatory reactions involving the skin and the gastrointestinal tract are among the most common adverse events seen with checkpoint inhibitors.

Checkpoint inhibitors side effects.

He says he figures these are just normal side effects of his medication. Fatigue weakness nausea confusion headache loss of appetite vision problems fever. Common side effects associated with currently approved checkpoint immunotherapies may include but are not limited to. Diarrhea pneumonitis inflammation in the lungs rashes and itchiness problems with some hormone levels kidney infections.

Occasional any grade toxicities in 5 20 of patients include fatigue headache arthralgia rash pruritus pneumonitis diarrhoea and or colitis hepatitis and endocrinopathies table 1. The most common side effects of checkpoint inhibitors are. On average symptoms appear around nine weeks after starting treatment and may include. Checkpoint inhibitor associated neurological side effects are rare but potentially life threatening.

Paying careful attention to potential symptoms is therefore crucial. However immune checkpoint blockade can lead to the breaking of immune self tolerance thereby inducing a novel syndrome of autoimmune autoinflammatory side effects designated as immune related adverse events mainly including rash colitis hepatitis and endocrinopathies. Since these drugs rev up your immune system they can cause a range of side effects including fatigue cough nausea loss of appetite rash and problems in your lungs kidneys intestines. Besides headache dizziness and apathy ataxia tremor paralysis myoclonus cognitive impairment speech disorders and even seizures may occur.

Other immune checkpoint inhibitors are under clinical evaluation.